Sarcosine dehydrogenase
In enzymology, a sarcosine dehydrogenase (EC 1.5.99.1) is an enzyme that catalyzes the chemical reaction
- sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
The 3 substrates of this enzyme are sarcosine, acceptor, and H2O, whereas its 3 products are glycine, formaldehyde, and reduced acceptor.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donor with other acceptors. The systematic name of this enzyme class is sarcosine:acceptor oxidoreductase (demethylating). Other names in common use include sarcosine N-demethylase, monomethylglycine dehydrogenase, and sarcosine:(acceptor) oxidoreductase (demethylating). This enzyme participates in glycine, serine and threonine metabolism. It employs one cofactor, FMN.
See also
References
- FRISELL WR, MACKENZIE CG (1962). "Separation and purification of sarcosine dehydrogenase and dimethylglycine dehydrogenase". J. Biol. Chem. 237: 94–8. PMID 13895406.
- HOSKINS DD, MACKENZIE CG (1961). "Solubilization and electron transfer flavoprtein requirement of mitochondrial sarcosine dehydrogenase and dimethylglycine dehydrogenase". J. Biol. Chem. 236: 177–83. PMID 13716069.
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| 1.5.1: NAD or NADP acceptor |
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| 1.5.3: oxygen acceptor |
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| 1.5.5: quinone acceptor |
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| 1.5.99 |
Sarcosine dehydrogenase
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B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
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